A novel deep hybrid Residual-SwinCA-Net segmentation framework is proposed in the study for addressing such challenges by extracting locally correlated and robust features, incorporating residual CNN modules. Furthermore, for learning global dependencies, Swin Transformer blocks are customized using internal residual pathways, which reinforce gradient stability, refine local patterns, and facilitate global feature fusion. Formerly, for enhancing tissue continuity, ultrasound noise suppressions, and accentuating fine structural transitions Laplacian-of-Gaussian regional operator is applied, and for maintaining the morphological integrity of malignant lesion contours, a boundary-oriented operator has been incorporated. Subsequently, a contraction strategy was applied stage-wise by progressively reducing features-map progressively for capturing scale invariance and enhancing the robustness of structural variability. In addition, each decoder level prior augmentation integrates a new Multi-Scale Channel Attention and Squeezing (MSCAS) module. The MSCAS selectively emphasizes encoder salient maps, retains discriminative global context, and complementary local structures with minimal computational cost while suppressing redundant activations. Finally, the Pixel-Attention module encodes class-relevant spatial cues by adaptively weighing malignant lesion pixels while suppressing background interference. The Residual-SwinCA-Net and existing CNNs/ViTs techniques have been implemented on the publicly available BUSI dataset. The proposed Residual-SwinCA-Net framework outperformed and achieved 99.29% mean accuracy, 98.74% IoU, and 0.9041 Dice for breast lesion segmentation. The proposed Residual-SwinCA-Net framework improves the BUSI lesion diagnostic performance and strengthens timely clinical decision-making.

The increasing prevalence of thyroid cancer globally has led to the development of various computer-aided detection methods. Accurate segmentation of thyroid nodules is a critical first step in the development of AI-assisted clinical decision support systems. This study focuses on instance segmentation of thyroid nodules using YOLOv5 algorithms on ultrasound images. We evaluated multiple YOLOv5 variants (Nano, Small, Medium, Large, and XLarge) across two dataset versions, with and without doppler images. The YOLOv5-Large algorithm achieved the highest performance with a dice score of 91\% and mAP of 0.87 on the dataset including doppler images. Notably, our results demonstrate that doppler images, typically excluded by physicians, can significantly improve segmentation performance. The YOLOv5-Small model achieved 79\% dice score when doppler images were excluded, while including them improved performance across all model variants. These findings suggest that instance segmentation with YOLOv5 provides an effective real-time approach for thyroid nodule detection, with potential clinical applications in automated diagnostic systems.

Ultrasound scanning is a critical imaging technique for real-time, non-invasive diagnostics. However, variations in patient anatomy and complex human-in-the-loop interactions pose significant challenges for autonomous robotic scanning. Existing ultrasound scanning robots are commonly limited to relatively low generalization and inefficient data utilization. To overcome these limitations, we present UltraDP, a Diffusion-Policy-based method that receives multi-sensory inputs (ultrasound images, wrist camera images, contact wrench, and probe pose) and generates actions that are fit for multi-modal action distributions in autonomous ultrasound scanning of carotid artery. We propose a specialized guidance module to enable the policy to output actions that center the artery in ultrasound images. To ensure stable contact and safe interaction between the robot and the human subject, a hybrid force-impedance controller is utilized to drive the robot to track such trajectories. Also, we have built a large-scale training dataset for carotid scanning comprising 210 scans with 460k sample pairs from 21 volunteers of both genders. By exploring our guidance module and DP's strong generalization ability, UltraDP achieves a 95% success rate in transverse scanning on previously unseen subjects, demonstrating its effectiveness.

Multi-task learning can suffer from destructive task interference, where jointly trained models underperform single-task baselines and limit generalization. To improve generalization performance in breast ultrasound-based tumor segmentation via multi-task learning, we propose a novel consistency regularization approach that mitigates destructive interference between segmentation and classification. The consistency regularization approach is composed of differentiable BI-RADS-inspired morphological features. We validated this approach by training all models on the BrEaST dataset (Poland) and evaluating them on three external datasets: UDIAT (Spain), BUSI (Egypt), and BUS-UCLM (Spain). Our comprehensive analysis demonstrates statistically significant (p<0.001) improvements in generalization for segmentation task of the proposed multi-task approach vs. the baseline one: UDIAT, BUSI, BUS-UCLM (Dice coefficient=0.81 vs 0.59, 0.66 vs 0.56, 0.69 vs 0.49, resp.). The proposed approach also achieves state-of-the-art segmentation performance under rigorous external validation on the UDIAT dataset.

Ultrasound-based risk stratification of thyroid nodules is a critical clinical task, but it suffers from high inter-observer variability. While many deep learning (DL) models function as "black boxes," we propose a fully automated, two-stage framework for interpretable malignancy prediction. Our method achieves interpretability by forcing the model to focus only on clinically relevant regions. First, a TransUNet model automatically segments the thyroid nodule. The resulting mask is then used to create a region of interest around the nodule, and this localised image is fed directly into a ResNet-18 classifier. We evaluated our framework using 5-fold cross-validation on a clinical dataset of 349 images, where it achieved a high F1-score of 0.852 for predicting malignancy. To validate its performance, we compared it against a strong baseline using a Random Forest classifier with hand-crafted morphological features, which achieved an F1-score of 0.829. The superior performance of our DL framework suggests that the implicit visual features learned from the localised nodule are more predictive than explicit shape features alone. This is the first fully automated end-to-end pipeline for both detecting thyroid nodules on ultrasound images and predicting their malignancy.

Abstract--Diagnostic medical ultrasound is widely used, safe, and relatively low cost but requires a high degree of expertise to acquire and interpret the images. Personnel with this expertise are often not available outside of larger cities, leading to difficult, costly travel and long wait times for rural populations. T o address this issue, tele-ultrasound techniques are being developed, including robotic teleoperation and recently human teleoperation, in which a novice user is remotely guided in a hand-overhand manner through mixed reality to perform an ultrasound exam. These methods have not been compared, and their relative strengths are unknown. Human teleoperation may be more practical than robotics for small communities due to its lower cost and complexity, but this is only relevant if the performance is comparable. This paper therefore evaluates the differences between human and robotic teleoperation, examining practical aspects such as setup time and flexibility and experimentally comparing performance metrics such as completion time, position tracking, and force consistency. It is found that human teleoperation does not lead to statistically significant differences in completion time or position accuracy, with mean differences of 1.8% and 0.5%, respectively, and provides more consistent force application despite being substantially more practical and accessible. Remote and under-resourced communities have far worse access to healthcare than larger cities [1], [2]. Ultrasound has become one of the most prevalent diagnostic imaging modalities due to its relatively low cost, non-invasive nature, and lack of radiation [3], but many communities have very limited access to qualified sonographers.

Ultrasound imaging is one of the most widely used diagnostic modalities, offering real-time, radiation-free assessment across diverse clinical domains. However, interpretation of ultrasound images remains challenging due to high noise levels, operator dependence, and limited field of view, resulting in substantial inter-observer variability. Current Deep Learning approaches are hindered by the scarcity of large labeled datasets and the domain gap between general and sonographic images, which limits the transferability of models pretrained on non-medical data. To address these challenges, we introduce the Ultrasound Self-Supervised Foundation Model with Masked Autoencoding (USF-MAE), the first large-scale self-supervised MAE framework pretrained exclusively on ultrasound data. The model was pre-trained on 370,000 2D and 3D ultrasound images curated from 46 open-source datasets, collectively termed OpenUS-46, spanning over twenty anatomical regions. This curated dataset has been made publicly available to facilitate further research and reproducibility. Using a Vision Transformer encoder-decoder architecture, USF-MAE reconstructs masked image patches, enabling it to learn rich, modality-specific representations directly from unlabeled data. The pretrained encoder was fine-tuned on three public downstream classification benchmarks: BUS-BRA (breast cancer), MMOTU-2D (ovarian tumors), and GIST514-DB (gastrointestinal stromal tumors). Across all tasks, USF-MAE consistently outperformed conventional CNN and ViT baselines, achieving F1-scores of 81.6%, 79.6%, and 82.4%, respectively. Despite not using labels during pretraining, USF-MAE approached the performance of the supervised foundation model UltraSam on breast cancer classification and surpassed it on the other tasks, demonstrating strong cross-anatomical generalization.

Pediatric appendicitis remains one of the most common causes of acute abdominal pain in children, and its diagnosis continues to challenge clinicians due to overlapping symptoms and variable imaging quality. This study aims to develop and evaluate a deep learning model based on a pretrained ResNet architecture for automated detection of appendicitis from ultrasound images. We used the Regensburg Pediatric Appendicitis Dataset, which includes ultrasound scans, laboratory data, and clinical scores from pediatric patients admitted with abdominal pain to Children Hospital. Hedwig in Regensburg, Germany. Each subject had 1 to 15 ultrasound views covering the right lower quadrant, appendix, lymph nodes, and related structures. For the image based classification task, ResNet was fine tuned to distinguish appendicitis from non-appendicitis cases. Images were preprocessed by normalization, resizing, and augmentation to enhance generalization. The proposed ResNet model achieved an overall accuracy of 93.44, precision of 91.53, and recall of 89.8, demonstrating strong performance in identifying appendicitis across heterogeneous ultrasound views. The model effectively learned discriminative spatial features, overcoming challenges posed by low contrast, speckle noise, and anatomical variability in pediatric imaging.

Breast cancer is a leading cause of death among women worldwide, emphasizing the need for early detection and accurate diagnosis. As such Ultrasound Imaging, a reliable and cost-effective tool, is used for this purpose, however the sensitive nature of medical data makes it challenging to develop accurate and private artificial intelligence models. A solution is Federated Learning as it is a promising technique for distributed machine learning on sensitive medical data while preserving patient privacy. However, training on non-Independent and non-Identically Distributed (non-IID) local datasets can impact the accuracy and generalization of the trained model, which is crucial for accurate tumour boundary delineation in BC segmentation. This study aims to tackle this challenge by applying the Federated Proximal (FedProx) method to non-IID Ultrasonic Breast Cancer Imaging datasets. Moreover, we focus on enhancing tumour segmentation accuracy by incorporating a modified U-Net model with attention mechanisms. Our approach resulted in a global model with 96% accuracy, demonstrating the effectiveness of our method in enhancing tumour segmentation accuracy while preserving patient privacy. Our findings suggest that FedProx has the potential to be a promising approach for training precise machine learning models on non-IID local medical datasets.

These authors contributed equally to this work Abstract: Liver disease is a major global health burden. While ultrasound is the first-line diagnostic tool, liver sonography requires locating multiple non-continuous planes from positions where target structures are often not visible, for biometric assessment and lesion detection, requiring significant expertise. However, expert sonographers are severely scarce in resource-limited regions. Here, we develop an autonomous lightweight ultrasound robot comprising an AI agent that integrates multi-modal perception with memory attention for localization of unseen target structures, and a 588-gram 6-degrees-of-freedom cable-driven robot. By mounting on the abdomen, the system enhances robustness against motion. Our robot can autonomously acquire expert-level standard liver ultrasound planes and detect pathology in patients, including two from Xining, a 2261-meter-altitude city with limited medical resources. Our system performs effectively on rapid-motion individuals and in wilderness environments. This work represents the first demonstration of autonomous sonography across multiple challenging scenarios, potentially transforming access to expert-level diagnostics in underserved regions. One-Sentence Summary: The lightweight robot enables autonomous liver non-continuous standard plane sonography across multiple scenarios. Main Text: INTRODUCTION Liver disease represents a major global health burden, accounting for over two million deaths annually--approximately 4% of worldwide mortality. Cirrhosis and hepatocellular carcinoma constitute the predominant causes of liver-related fatalities. Meanwhile, parasitic infections pose additional challenges, particularly in resource-limited settings ( 1-3).